Tyrothricin |
| カタログ番号GC18414 |
チロスリシンは、バチルス ブレビスから分離されたポリペプチド抗生物質混合物であり、チロシジンとグラミシジンで構成されています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1404-88-2
Sample solution is provided at 25 µL, 10mM.
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Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.[1] [2]Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica. Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections. [1][2]
Reference:
[1]. Dubos, R.J., and Hotchkiss, R.D. The production of bactericidal substances by aerobic sporulating bacilli. J. Exp. Med. 73(5), 629-640 (1941).
[2]. Lask, S.A. Tyrothricin as an antibiotic. Arch. Surg. 56(4), 475-483 (1948).
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