1-Oleoyl lysophosphatidic acid sodium salt (Synonyms: Oleoyl-sn-3-glycerophosphate) |
| Catalog No.GC15140 |
1-올레오일 리소인산 (1-Oleoyl-sn-glycero-3-phosphate) 나트륨은 강력한 생체 활성 인지질로, LPA 수용체 활성제입니다.
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Cas No.: 325465-93-8
Sample solution is provided at 25 µL, 10mM.
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1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, as a potent bioactive phospholipid, is a LPA receptor activator[1][2].
In vitro, 0.1 - 10 µM 1-Oleoyl-sn-glycero-3-phosphate elicits an acute rise of [Ca2+]i in rat and rabbit osteoclasts[1]. In addition, 1–5 μm 1-Oleoyl-sn-glycero-3-phosphate enhances osteoclast survival[1].
An ether-linked LPA (1-O-hexadecylglycerol 3-phosphate) has much decreased mitogenic activity as compared with the ester-linked analogue at concentrations less than 25 µM, and becomes cytotoxic at higher concentrations[2].
References:
[1] Lapierre DM, et al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010 Aug 13;285(33):25792-801.
[2] van Corven EJ, et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):163-9.
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