A-196 |
| Catalog No.GC32861 |
A-196은 각각 25nM 및 144nM의 IC50 값을 갖는 SUV420H1 및 SUV420H2의 강력하고 선택적인 억제제입니다. A-196은 기질 경쟁 방식으로 SUV4-20을 생화학적으로 억제합니다. A-196은 게놈 무결성에서 히스톤 메틸트랜스퍼라제의 역할을 조사하기 위한 SUV4-20의 동급 최초의 화학 프로브를 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1982372-88-2
Sample solution is provided at 25 µL, 10mM.
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A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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