ChX710 |
| Catalog No.GC34329 |
ChX710은 ISRE 프로모터 서열, 특정 세포 인터페론 자극 유전자(ISG) 및 인터페론 조절 인자(IRF) 3의 인산화를 유도하는 세포질 DNA에 대한 I형 인터페론 반응을 프라이밍할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2438721-44-7
Sample solution is provided at 25 µL, 10mM.
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ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
ChX710 treatment is found to efficiently prime the cellular response to DNA transfection via STING as assessed by strong synergistic effects on IFN-β expression at both transcriptional and protein levels [1].
[1]. Khiar S, et al. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017 May 31;7(1):2561.
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