>>Signaling Pathways>> Metabolism>> Sterol Biosynthesis>>CAY10485

CAY10485 (Synonyms: 3,4dihydroxy Hydrocinnamic acid (LAspartic acid dibenzyl ester) amide)

Catalog No.GC43160

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.

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CAY10485 Chemical Structure

Cas No.: 615264-62-5

Size 가격 재고 수량
5mg
US$47.00
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10mg
US$91.00
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50mg
US$384.00
재고 있음
100mg
US$672.00
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Sample solution is provided at 25 µL, 10mM.

Description of CAY10485

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.

Chemical Properties of CAY10485

Cas No. 615264-62-5 SDF
Synonyms 3,4dihydroxy Hydrocinnamic acid (LAspartic acid dibenzyl ester) amide
Canonical SMILES O=C(CCc1ccc(O)c(O)c1)N[C@@H](CC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Formula C27H27NO7 M.Wt 477.5
Solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:3): .25 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CAY10485

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0942 mL 10.4712 mL 20.9424 mL
5 mM 0.4188 mL 2.0942 mL 4.1885 mL
10 mM 0.2094 mL 1.0471 mL 2.0942 mL
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In vivo Formulation Calculator (Clear solution) of CAY10485

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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