CAY10485 (Synonyms: 3,4dihydroxy Hydrocinnamic acid (LAspartic acid dibenzyl ester) amide) |
| カタログ番号GC43160 |
アシルコエンザイムA：コレステロールアシルトランスフェラーゼ-1および-2（ACAT-1およびACAT-2）は、コレステロールと長鎖脂肪族アシルコエンザイムAからのコレステロールエステルの形成を触媒し、動脈硬化の発症に関与する可能性があります。
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Cas No.: 615264-62-5
Sample solution is provided at 25 µL, 10mM.
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Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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