Cefazolin (sodium salt) (Synonyms: Ancef®,Biazolina,Elzogram,Gramaxin,Kefzolan,Kezolin,NSC 291561,SKF 41558) |
Catalog No.GC10179
One-Click Copy Product Info
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세파졸린(나트륨염)은 1세대 세팔로스포린 항생제이며 다양한 세균 감염 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27164-46-1
Sample solution is provided at 25 µL, 10mM.
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Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
In vitro: In cultured MG-63 human osteosarcoma cell line, cefazolin (100 μg/ml) showed little or no effect on osteoblast replication. Cefazolin (200μg/ml) significantly decreased cell replication, and 10,000 μg/ml caused cell death [2].
In vivo: In patients with normal and various degrees of compromised renal function, administration of cefazolin significantly decreased the urinary concentration and percentage of the dose excreted in the urine [3]. The half-life of cefazolin in serum of normal persons was 1.9 hr and as long as 35 hr in severely uremic patients. In uremic patients, cefazolin was well tolerated [4].
References:
[1] Kariyone K, HARADA H, KURITA M, et al. Cefazolin, a new semisynthetic cephalosporin antibiotic. I[J]. The Journal of antibiotics, 1970, 23(3): 131-136.
[2] Edin M L, Miclau T, Lester G E, et al. Effect of cefazolin and vancomycin on osteoblasts in vitro[J]. Clinical orthopaedics and related research, 1996, 333: 245-251.
[3] Levison M E, Levison S P, Ries K, et al. Pharmacology of cefazolin in patients with normal and abnormal renal function[J]. Journal of Infectious Diseases, 1973, 128(Supplement 2): S354-S357.
[4] Craig W A, Welling P G, Jackson T C, et al. Pharmacology of cefazolin and other cephalosporins in patients with renal insufficiency[J]. Journal of Infectious Diseases, 1973, 128(Supplement 2): S347-S353.
| Cas No. | 27164-46-1 | SDF | |
| Synonyms | Ancef®,Biazolina,Elzogram,Gramaxin,Kefzolan,Kezolin,NSC 291561,SKF 41558 | ||
| Chemical Name | (6R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7R-[[2-(1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt | ||
| Canonical SMILES | O=C(CN1N=NN=C1)N[C@H](C2=O)[C@]3([H])N2C(C([O-])=O)=C(CSC4=NN=C(C)S4)CS3.[Na+] | ||
| Formula | C14H13N8O4S3 • Na | M.Wt | 476.5 |
| Solubility | ≥ 25.5mg/mL in DMSO | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0986 mL | 10.4932 mL | 20.9864 mL |
| 5 mM | 419.7 μL | 2.0986 mL | 4.1973 mL |
| 10 mM | 209.9 μL | 1.0493 mL | 2.0986 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)