Cefazolin (sodium salt) (Synonyms: Ancef®,Biazolina,Elzogram,Gramaxin,Kefzolan,Kezolin,NSC 291561,SKF 41558) |
| Catalog No.GC10179 |
Cefazolin (sodium salt) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27164-46-1
Sample solution is provided at 25 µL, 10mM.
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Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
In vitro: In cultured MG-63 human osteosarcoma cell line, cefazolin (100 μg/ml) showed little or no effect on osteoblast replication. Cefazolin (200μg/ml) significantly decreased cell replication, and 10,000 μg/ml caused cell death [2].
In vivo: In patients with normal and various degrees of compromised renal function, administration of cefazolin significantly decreased the urinary concentration and percentage of the dose excreted in the urine [3]. The half-life of cefazolin in serum of normal persons was 1.9 hr and as long as 35 hr in severely uremic patients. In uremic patients, cefazolin was well tolerated [4].
References:
[1] Kariyone K, HARADA H, KURITA M, et al. Cefazolin, a new semisynthetic cephalosporin antibiotic. I[J]. The Journal of antibiotics, 1970, 23(3): 131-136.
[2] Edin M L, Miclau T, Lester G E, et al. Effect of cefazolin and vancomycin on osteoblasts in vitro[J]. Clinical orthopaedics and related research, 1996, 333: 245-251.
[3] Levison M E, Levison S P, Ries K, et al. Pharmacology of cefazolin in patients with normal and abnormal renal function[J]. Journal of Infectious Diseases, 1973, 128(Supplement 2): S354-S357.
[4] Craig W A, Welling P G, Jackson T C, et al. Pharmacology of cefazolin and other cephalosporins in patients with renal insufficiency[J]. Journal of Infectious Diseases, 1973, 128(Supplement 2): S347-S353.
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