Cintirorgon (LYC-55716) (Synonyms: LYC-55716) |
Catalog No.GC32713 |
Cintirorgon(LYC-55716)(LYC-55716)은 동급 최초의 선택적 경구 생체이용 가능한 RORγ입니다. 작용제. Cintirorgon(LYC-55716)(LYC-55716)은 RORγ의 유전자 발현을 조절합니다. T 림프구 면역 세포를 발현하여 효과기 기능이 향상되고 면역 억제가 감소하여 종양 성장이 감소하고 생존이 향상됩니다.
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Cas No.: 2055536-64-4
Sample solution is provided at 25 µL, 10mM.
Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.
Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improves survival in in vivo. Upon oral administration of RORγ agonist Cintirorgon (LYC-55716), this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). This may increase the expression of co-stimulatory molecules and decrease the expression of co-inhibitory molecules on T cells leading to increased production of cytokines and chemokines by T cells, decreases proliferation of regulatory T cells (Tregs), and abrogation of tumor-induced immunosuppression. This ultimately induces a T-cell-mediated immune response against cancer cells and leads to a reduction in tumor cell growth. RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation. Cintirorgon (LYC-55716) is also orally bioavailable, while the new generation of immuno-oncology drugs-ncluding PD-1/PD-L1 inhibitors are delivered by injection[1].
[1]. Lycera Announces Initiation of Phase 1/2a Study ARGON of Immuno-Oncology Candidate LYC-55716 in Patients with Advanced Solid Tumors. Jan 04, 2017.
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