Cirsimaritin (Synonyms: 5,4'-Dihydroxy-6,7-dimethoxyflavone) |
| Catalog No.GC31120 |
Cirsimaritin은 GABAA 수용체의 benzodiazepine 부위에 약하게 결합하여 항우울제, 항불안제 및 항침해수용 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6601-62-3
Sample solution is provided at 25 µL, 10mM.
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Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.
Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds[1].
[1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.
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