Demethylwedelolactone |
| Catalog No.GC43407 |
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6468-55-9
Sample solution is provided at 25 µL, 10mM.
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Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities. It reduces cytotoxicity induced by CCL4 and galactosamine in rat hepatocytes in a dose-dependent manner. DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro. It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom. DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.
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