FCE 28654 |
| Catalog No.GC31384 |
FCE 28654는 acylCoA: 콜레스테롤 아실트랜스퍼라제(ACAT)의 억제제로 토끼 대동맥과 장, 원숭이 간 마이크로솜에서 ACAT를 약하게 억제하며 IC50은 각각 2.55, 1.08, 5.69μM입니다.
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Cas No.: 169474-77-5
Sample solution is provided at 25 µL, 10mM.
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FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1].
FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1].
[1]. A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586.
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