CDC25B-IN-1 |
Catalog No.GC35627 |
CDC25B-IN-1(화합물 4a)은 8.5μM의 Ki를 갖는 세포 분열 주기 25B(CDC25B) 포스파타제의 강력한 억제제이다. CDC25B-IN-1은 세포 증식과 집락 형성을 강력하게 억제하여 G2/M기의 증가를 유발합니다.
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Cas No.: 2374831-10-2
Sample solution is provided at 25 µL, 10mM.
CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1]. Ki: 8.5 μM (CDC25B phosphatase)[1]
[1]. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62(15):7089-7110.
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