MD2-TLR4-IN-1 |
| Catalog No.GC36578 |
MD2-TLR4-IN-1(화합물 22m)은 골수 분화 단백질 2/톨 유사 수용체 4(MD2-TLR4) 복합체의 억제제로, 종양 괴사 인자 알파(TNF-α)의 지질다당류(LPS) 유도 발현을 억제합니다. IC50 값이 각각 0.89μM 및 0.53μM인 대식세포의 인터루킨-6(IL-6).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2249801-12-3
Sample solution is provided at 25 µL, 10mM.
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MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. MD2-TLR4[1].
[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.
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