OP-3633 |
| Katalog-Nr.GC36809 |
OP-3633 ist ein potenter und selektiver Steroid-Glucocorticoid-Rezeptor (GR)-Antagonist mit einem IC50-Wert von 29 nM, der die TranskriptionsaktivitÄt von GR hemmt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102494-14-2
Sample solution is provided at 25 µL, 10mM.
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OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1]. IC50: 29 nM (GR)[1]
OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1]. OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].
[1]. Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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