PF-06263276 |
| Catalog No.GC36882 |
PF-06263276(PF 6263276)은 JAK1, JAK2, JAK3 및 TYK2에 대해 IC50이 각각 2.2nM, 23.1nM, 59.9nM 및 29.7nM인 강력하고 선택적인 pan-JAK 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1421502-62-6
Sample solution is provided at 25 µL, 10mM.
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PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1]. JAK1|2.2 nM (IC50)|JAK2|23.1 nM (IC50)|JAK3|59.9 nM (IC50)|Tyk2|29.7 nM (IC50)
[1]. Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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