Taccalonolide A |
| Catalog No.GC37715 |
Taccalonolide A는 Tacca chantrieri에서 분리된 스테로이드로 세포독성 및 항말라리아 활성을 갖는 미세소관 안정제입니다. Taccalonolide A는 G2-M 축적, Bcl-2 인산화 및 세포 사멸의 시작을 유발합니다. Taccalonolide A는 SK-OV-3 세포에 대해 622nM의 IC50으로 P-당단백질(Pgp) 및 다제내성 단백질 7(MRP7)을 과발현하는 세포주에 대해 시험관 내에서 효과적입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108885-68-3
Sample solution is provided at 25 µL, 10mM.
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Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3]. microtubule[1]
[1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20. [2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9. [3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.
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