Taccalonolide A |
| Katalog-Nr.GC37715 |
Taccalonolide A ist ein Mikrotubuli-Stabilisator, ein aus Tacca chantrieri isoliertes Steroid mit zytotoxischen und Antimalaria-AktivitÄten. Taccalonolid A verursacht eine G2-M-Akkumulation, Bcl-2-Phosphorylierung und die Initiierung von Apoptose. Taccalonolide A ist in vitro wirksam gegen Zelllinien, die P-Glycoprotein (Pgp) und Multidrug Resistance Protein 7 (MRP7) Überexprimieren, mit einem IC50-Wert von 622 nM fÜr SK-OV-3-Zellen.
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Cas No.: 108885-68-3
Sample solution is provided at 25 µL, 10mM.
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Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3]. microtubule[1]
[1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20. [2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9. [3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.
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