HS-10296 hydrochloride |
| Catalog No.GC33053 |
알모네르티닙(HS-10296) 염산염은 EGFR 민감성 및 T790M 내성 돌연변이에 대해 높은 선택성을 가진 경구 사용 가능한 비가역적 3세대 EGFR 티로신 키나제 억제제입니다. HS-10296 염산염은 T790M, T790M/L858R, T790M/Del19(IC50: 각각 0.37, 0.29, 0.21 nM)에 대해 큰 억제 활성을 보이며, 야생형(3.39 nM)에 대해서는 덜 효과적이다. HS-10296 염산염은 비소세포폐암 연구에 사용됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2134096-03-8
Sample solution is provided at 25 µL, 10mM.
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HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].
[1]. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76. [2]. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.
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