INT-767 |
| Catalog No.GC32742 |
INT-767은 각각 30 및 630nM의 평균 EC50을 갖는 이중 파르네소이드 X 수용체(FXR)/TGR5 작용제입니다.
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Cas No.: 1000403-03-1
Sample solution is provided at 25 µL, 10mM.
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INT-767 is a dual farnesoid X receptor/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
[1]. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.
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