INT-767 |
| Katalog-Nr.GC32742 |
INT-767 ist ein dualer Farnesoid-X-Rezeptor (FXR)/TGR5-Agonist mit mittleren EC50-Werten von 30 bzw. 630 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1000403-03-1
Sample solution is provided at 25 µL, 10mM.
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INT-767 is a dual farnesoid X receptor/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
[1]. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.
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