>>JNJ-46281222

JNJ-46281222

Catalog No.GC39393

JNJ-46281222는 나노몰 친화도(Kd = 1.7 nM)와 높은 조절 효능(pEC50= 7.71)을 가진 대사성 글루타메이트(mGlu) 2-선택적, 매우 강력한 PAM(양성 알로스테릭 조절제)입니다.

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JNJ-46281222 Chemical Structure

Cas No.: 1254980-38-5

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$459.00
재고 있음
5mg
US$417.00
재고 있음
10mg
US$695.00
재고 있음
50mg
US$2,086.00
재고 있음
100mg
US$3,569.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

[1]. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.

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