JNJ-46281222 |
Catalog No.GC39393 |
JNJ-46281222는 나노몰 친화도(Kd = 1.7 nM)와 높은 조절 효능(pEC50= 7.71)을 가진 대사성 글루타메이트(mGlu) 2-선택적, 매우 강력한 PAM(양성 알로스테릭 조절제)입니다.
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Cas No.: 1254980-38-5
Sample solution is provided at 25 µL, 10mM.
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].
[1]. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.
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