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JNJ-46281222

Katalog-Nr.GC39393

JNJ-46281222 ist ein metabotropes Glutamat (mGlu) 2-selektives, hochpotentes PAM (positiver allosterischer Modulator) mit nanomolarer AffinitÄt (Kd = 1,7 nM) und einer hohen modulatorischen Potenz (pEC50= 7,71).

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JNJ-46281222 Chemische Struktur

Cas No.: 1254980-38-5

Größe Preis Lagerbestand Menge
10mM (in 1mL DMSO)
459,00 $
Auf Lager
5mg
417,00 $
Auf Lager
10mg
695,00 $
Auf Lager
50mg
2.086,00 $
Auf Lager
100mg
3.569,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

[1]. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.

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