PARP-1-IN-2 |
| Catalog No.GC64579 |
PARP-1-IN-2(화합물 11g)는 IC50이 149nM인 강력한 BBB 침투 PARP1 억제제입니다. PARP1-IN-2는 인간 폐 선암종 상피 세포주 A549에 대해 상당히 강력한 항증식 활성을 나타냅니다. PARP1-IN-2는 A549 세포의 세포사멸을 유도할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 684234-55-7
Sample solution is provided at 25 µL, 10mM.
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PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1[1].
[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
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