PARP-1-IN-2 |
| カタログ番号GC64579 |
PARP-1-IN-2 (化合物 11g) は、149 nM の IC50 を持つ強力な BBB 浸透 PARP1 阻害剤です。 PARP1-IN-2 は、ヒト肺腺癌上皮細胞株 A549 に対して非常に強力な抗増殖活性を示します。 PARP1-IN-2 は、A549 細胞のアポトーシスを誘導することができます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 684234-55-7
Sample solution is provided at 25 µL, 10mM.
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PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1[1].
[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
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