Penitrem A (Synonyms: NSC 354845, Tremortin A) |
| Catalog No.GC11608 |
Penitrem A는 Penicillium이 생산하는 인돌 디테르펜 신경독성 알칼로이드로 다발성 악성종양에 대한 항증식 및 항침습 활성을 갖는 선택적 BK 채널 길항제 역할을 합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 12627-35-9
Sample solution is provided at 25 µL, 10mM.
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Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].
References:
[1]. Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5).
[2]. Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.
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