PF-02575799 |
| Catalog No.GC31522 |
PF-02575799는 IC50이 0.77±0.29nM인 마이크로솜 트리글리세리드 전달 단백질(MTP) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 863491-70-7
Sample solution is provided at 25 µL, 10mM.
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PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
PF-02575799 is compound 13 from the reference[1].
PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg[1].
[1]. Robinson RP, et al. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4.
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