S-trityl-L-Cysteine (Synonyms: NSC 83265) |
| Catalog No.GC40932 |
S-트리틸-L-시스테인(NSC 83265)은 기본 ATPase 활성 억제에 대한 IC50이 1μM이고 미세소관 활성화 ATPase 활성에 대해 140nM인 선택적 알로스테릭 키네신 Eg5 억제제입니다. S-트리틸-L-시스테인은 항종양 활성이 있습니다.
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Cas No.: 2799/7/7
Sample solution is provided at 25 µL, 10mM.
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S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 µM) and in mouse xenograft models.
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