SAR125844 |
| Catalog No.GC33189 |
SAR125844는 IC50이 4.2nM인 강력하고 고도로 선택적이고 가역적이며 ATP 경쟁적인 MET 수용체 티로신 키나제(RTK) 억제제입니다. 세포 기반 분석에서 MET 자가인산화의 억제를 보여줍니다.
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Cas No.: 1116743-46-4
Sample solution is provided at 25 µL, 10mM.
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SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor for intravenous administration, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1].
[1]. Egile C, et al. The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94.
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