Seneciphylline (Synonyms: NSC 30622) |
| Catalog No.GC44882 |
세네시필린은 세네시오 식물의 독성 피롤리지딘 알칼로이드입니다. Seneciphylline은 epoxide hydrase와 glutathione-S-transferase의 활성을 크게 증가시키지만 cytochrome P-450과 관련된 monooxygenase 활성을 감소시킨다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 480-81-9
Sample solution is provided at 25 µL, 10mM.
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Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites. It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner. Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM). Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila. Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.
| Cas No. | 480-81-9 | SDF | |
| Synonyms | NSC 30622 | ||
| Canonical SMILES | O=C(/C(CC([C@@]1(C)O)=C)=C\C)O[C@]2([H])CCN3[C@]2([H])C(COC1=O)=CC3 | ||
| Formula | C18H23NO5 | M.Wt | 333.4 |
| Solubility | DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9994 mL | 14.997 mL | 29.994 mL |
| 5 mM | 0.5999 mL | 2.9994 mL | 5.9988 mL |
| 10 mM | 0.2999 mL | 1.4997 mL | 2.9994 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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