Seneciphylline (Synonyms: NSC 30622) |
Catalog No.GC44882 |
세네시필린은 세네시오 식물의 독성 피롤리지딘 알칼로이드입니다. Seneciphylline은 epoxide hydrase와 glutathione-S-transferase의 활성을 크게 증가시키지만 cytochrome P-450과 관련된 monooxygenase 활성을 감소시킨다.
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Cas No.: 480-81-9
Sample solution is provided at 25 µL, 10mM.
Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites. It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner. Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM). Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila. Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.
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