Seneciphylline (Synonyms: NSC 30622) |
Catalog No.GC44882 |
La sénéciphylline est un alcaloÏde pyrrolizidine toxique dans les plantes Senecio. La sénéciphylline augmente significativement les activités de l'époxyde hydrase et de la glutathion-S-transférase, mais provoque une réduction des activités du cytochrome P-450 et des monooxygénases associées.
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Cas No.: 480-81-9
Sample solution is provided at 25 µL, 10mM.
Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites. It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner. Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM). Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila. Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.
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