Seneciphylline (Synonyms: NSC 30622) |
| Katalog-Nr.GC44882 |
Seneciphyllin ist ein giftiges Pyrrolizidinalkaloid in Senecio-Pflanzen. Seneciphyllin erhÖht signifikant die AktivitÄten von Epoxidhydrase und Glutathion-S-Transferase, verursacht jedoch eine Verringerung von Cytochrom P-450 und verwandten Monooxygenase-AktivitÄten.
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Cas No.: 480-81-9
Sample solution is provided at 25 µL, 10mM.
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Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites. It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner. Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM). Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila. Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.
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