SPI 112 |
Catalog No.GC46011 |
SPI 112는 SHP2, 단백질 티로신 포스파타제(PTP) 및 PTP1B에 대해 IC50이 각각 1μM, 18.3μM 및 14.5μM인 강력하고 선택적이며 경쟁력 있는 SHP2(PTPN11) 억제제입니다.
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Cas No.: 1051387-90-6
Sample solution is provided at 25 µL, 10mM.
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 μM).1 It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 μM, respectively).
|1. Lawrence, H.R., Pireddu, R., Chen, L., et al. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J. Med. Chem. 51(16), 4548-4956 (2008).
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