Tandospirone hydrochloride (Synonyms: SM-3997 hydrochloride) |
| Catalog No.GC50031 |
탄도스피론(SM-3997) 염산염은 Ki가 27nM인 강력하고 선택적인 5-HT1A 수용체 부분 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 99095-10-0
Sample solution is provided at 25 µL, 10mM.
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5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID:1974152 |Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID:1358655 |Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 1112 126 PMID:16884702
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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