DNA Damage/DNA Repair

HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor.

HDAC6-IN-23 (compound 9) is an orally active HDAC6 inhibitor.

TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM.

Cu(II)-Elesclomol is a 1:1 chelate formed by Elesclomol and Cu (II) ions, which can induce copper death and has anti-cancer activity.

KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM.

PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively.

PARP7-IN-16 free base is the free base form of PARP7-IN-16.

ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase.

WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor.

WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor.

WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor.

Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and an Exatecan analogue.

(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent.

NH2-metlpropanamide-Exatecan TFA is a metlpropanamide-modified Exatecan , which is the common ADC Cytotoxin used in the synthesis of ADC.

DHX9-IN-2 (example 31) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the EC50 of 0.054 μM in circBRIP1.

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively.

Exatecan-metlacetamide-OH (compound 6) is a Exatecan derivative with anticancer effects.

ITF 3756 is a potent and selective HDAC6 inhibitor.

PARG-IN-4 (Formula (A)) is an orally active and cell-permeable PARG inhibitor.

HDAC6-IN-26 (compound 23) is a potent inhibitor of HDAC6.

DEG-77, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h).

Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate for ADC (ADC Cytotoxin: Exatecan).

Ribociclib-d8 is the deuterium labeled Ribociclib.

Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1.