DNA Damage/DNA Repair
Research Areas
- MTH1(4)
- PARP(103)
- ATM/ATR(31)
- DNA Alkylating(23)
- DNA Ligases(3)
- DNA Methyltransferase(27)
- DNA-PK(28)
- HDAC(143)
- Nucleoside Antimetabolite/Analogue(194)
- Telomerase(15)
- Topoisomerase(193)
- tankyrase(5)
- Antifolate(33)
- CDK(299)
- Checkpoint Kinase (Chk)(36)
- CRISPR/Cas9(9)
- Deubiquitinase(84)
- DNA Alkylator/Crosslinker(87)
- DNA/RNA Synthesis(575)
- Eukaryotic Initiation Factor (eIF)(33)
- IRE1(25)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(59)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(5)
- Early 2 Factor (E2F)(2)
- Zinc Finger Protein(1)
Products Related to DNA Damage/DNA Repair(1968)
- GF04054PROTAC CDK9 degrader-4CAS: 2411021-01-5Purity: >95.00%
PROTAC CDK9 degrader-4 is a PROTAC protein degrader that targets CDK9 (cyclin-dependent kinase 9).
- GN10208Berberine hydrochlorideCAS: 633-65-8Purity: >97.00%
Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections.
- GN20030N1-Methyladenosine-5'-TriphosphatePurity: >90.00%
N1-Methyladenosine-5'-Triphosphate is a synthetic nucleoside triphosphate derivative.
- GN201455'-Biotin-G-MonophosphateCAS: 2101200-52-4Purity: >95.00%
5-Biotin-G-Monophosphate allows the incorporation of biotin at the 5' end of RNA and is particularly useful for the development of aptamers.
- GN20149m7G(5')ppp(5')(2'OMeA)pGPurity: >99.50%
m7G(5')ppp(5')(2'OMeA)pG is an mRNA 5′cap analog belonging to the Cap 1 class with a 2′-O-methyl modification.
- GN20150CleanCap Reagent AUPurity: >95.00%
CleanCap Reagent AU is specifically designed for co-transcriptional capping, with the structure m7G(5')ppp(5')(2'OMeA)pU, to produce mRNA with a natural Cap1 structure.
- GC10098(S)-10-HydroxycamptothecinCAS: 19685-09-7Purity: >99.00%
(S)-10-Hydroxycamptothecin, a natural alkaloid found in plants, acts as a potent BRD4 inhibitor, with an IC 50 of 928.1nM.
- GC10734β-LapachoneCAS: 4707-32-8Purity: >98.00%
β-Lapachone is an ortho-naphthoquinone natural product, promoting several biological effects, such as anti-inflammatory, antibacterial, and anti-Trypanosoma, and β-Lapachone can inhibit topoisomerase I and induce NAD(P)H: quinone oxidoreductase 1.
- GC11048Irinotecan HCl TrihydrateCAS: 136572-09-3Purity: >99.00%
Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity.
- GC13359Topotecan HClCAS: 119413-54-6Purity: >99.00%
Topotecan HCl (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
- GC16455FlumequineCAS: 42835-25-6Purity: >99.00%
Flumequine is a fluoroquinolone antibiotic with favorable bioavailability and acts as an inhibitor of topoisomerase II, with an IC 50 value of 15μM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GE10003 | RNase R | - | - | |
RNase R is an E. coli exoribonuclease which exhibits 3’-to-5’ exonuclease activity, efficiently digesting nearly all linear RNA species. | ||||
| GF04054 | PROTAC CDK9 degrader-4 | 2411021-01-5 | >95.00% | |
PROTAC CDK9 degrader-4 is a PROTAC protein degrader that targets CDK9 (cyclin-dependent kinase 9). | ||||
| GN10017 | Wogonin | 632-85-9 | >98.00% | |
Wogonin is a potent and competitive inhibitor of CYP1A2 with a K i value of 0.24μM. | ||||
| GN10035 | 9-Methoxycamptothecin | 19685-10-0 | >99.00% | |
| GN10208 | Berberine hydrochloride | 633-65-8 | >97.00% | |
Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections. | ||||
| GN10221 | Berberine | 2086-83-1 | >99.50% | |
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. | ||||
| GN10306 | Folic acid | 59-30-3 | >98.00% | |
| GN10449 | SN-38 (NK012) | 86639-52-3 | >99.50% | |
| GN10523 | Berberine Sulfate | 633-66-9 | >98% | |
| GN10526 | Cucurbitacin E | 18444-66-1 | >99.50% | |
| GN10696 | Garcinone C | 76996-27-5 | >98% | |
| GN20030 | N1-Methyladenosine-5'-Triphosphate | - | >90.00% | |
N1-Methyladenosine-5'-Triphosphate is a synthetic nucleoside triphosphate derivative. | ||||
| GN20145 | 5'-Biotin-G-Monophosphate | 2101200-52-4 | >95.00% | |
5-Biotin-G-Monophosphate allows the incorporation of biotin at the 5' end of RNA and is particularly useful for the development of aptamers. | ||||
| GN20149 | m7G(5')ppp(5')(2'OMeA)pG | - | >99.50% | |
m7G(5')ppp(5')(2'OMeA)pG is an mRNA 5′cap analog belonging to the Cap 1 class with a 2′-O-methyl modification. | ||||
| GN20150 | CleanCap Reagent AU | - | >95.00% | |
CleanCap Reagent AU is specifically designed for co-transcriptional capping, with the structure m7G(5')ppp(5')(2'OMeA)pU, to produce mRNA with a natural Cap1 structure. | ||||
| GC10098 | (S)-10-Hydroxycamptothecin | 19685-09-7 | >99.00% | |
(S)-10-Hydroxycamptothecin, a natural alkaloid found in plants, acts as a potent BRD4 inhibitor, with an IC 50 of 928.1nM. | ||||
| GC10734 | β-Lapachone | 4707-32-8 | >98.00% | |
β-Lapachone is an ortho-naphthoquinone natural product, promoting several biological effects, such as anti-inflammatory, antibacterial, and anti-Trypanosoma, and β-Lapachone can inhibit topoisomerase I and induce NAD(P)H: quinone oxidoreductase 1. | ||||
| GC11048 | Irinotecan HCl Trihydrate | 136572-09-3 | >99.00% | |
Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity. | ||||
| GC11747 | Amsacrine hydrochloride | 54301-15-4 | >98.50% | |
Topoisomerase 2 inhibitor | ||||
| GC13359 | Topotecan HCl | 119413-54-6 | >99.00% | |
Topotecan HCl (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. | ||||
| GC16455 | Flumequine | 42835-25-6 | >99.00% | |
Flumequine is a fluoroquinolone antibiotic with favorable bioavailability and acts as an inhibitor of topoisomerase II, with an IC 50 value of 15μM. | ||||
| GC17082 | Pirarubicin | 72496-41-4 | >98.00% | |
Topoisomerase II inhibitor;anthracycline antibiotic | ||||
| GC12326 | Amsacrine | 51264-14-3 | >99.50% | |
Topoisomerase 2 inhibitor | ||||
| GC11940 | 5-BrdU | 59-14-3 | >99.00% | |
5-BrdU (5-bromo-2-deoxundine5-BrdU) is a synthetic thymidine bromide analog that is commonly used to measure DNA synthesis and label dividing cells. | ||||