DNA Damage/DNA Repair

YCH2823 is an inhibitor of USP7 (IC50 = 49.6 nM; Kd = 0.117 μM).

AZD8421 is a selective CDK2 inhibitor (IC50: 9 nM) with selectivity for CDK1, CDK4 and CDK6.

VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase.

Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium).

Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules.

GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 µM for ChKl, ChK2, respectively.

F-SAHA is a HDAC inhibitor (HDACi) and its 18F labeled derivative can be used in tumor imaging research.

LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor.

DHX9-IN-3 (Compound 621) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research.

CB07-Exatecan is an ADC drug-Linker conjugate that can be used for the synthesis of ADCs.

Martinostat (drochloride) is a inhibitor of HDAC that can be labeled with radionuclides for diagnostic applications.

SJ3149 is a selective and potent in vitro and in vivo degrader of CK1α protein with broad antiproliferative activity.

DS17 is a molecular glue that acts as a potent degrader of cyclin K, with an EC50 of 13 nM.

USP7-IN-13 (Compound 101) is a USP7 inhibitor with an IC50 value of 0.2-1 μM, which can be used for the study of multiple myeloma.

MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan with IC50 of 22 μM.

BLU-222 is an orally active and highly selective CDK2 inhibitor.

DBCO-β-Glu-PEG12-Exatecan (Compound 107) is an inhibitor for topoisomerase I.

WRN inhibitor 8 (Example 224) is a WRN helicase inhibitor with IC50 value of 48 nM.

AZD-9574-acid (70D), a PPAR-1 inhibitor, can be used for the synthesis of PROTAC (CAS 2923686-70-6).

YSR734 (Compound 21) is a covalent HDAC inhibitor with IC50 values of 110 nM, 154 nM, and 143 nM for HDAC1, HDAC2, and HDAC3, respectively.

CM-1758 is a histone deacetylase (HDAC) inhibitor.

Cyclin K degrader 1 (compound 40) is an AT7519 based Cyclin K degrader with DC50 of 21 nM.

Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively.

SE-7552, a 2-(difluorometl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-droxamate HDAC6 inhibitor with an IC50 of 33 nM.