DNA Damage/DNA Repair

UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal drolase L1 (UCHL1), with an IC50 of 5.1 μM.

METTL16-IN-1 (Compound 45) is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM.

INX-315 is an orally active and selective CDK2 inhibitor that induces cell cycle arrest in the G1 phase.

CDDD11-8 is an orally active, potent and selective inhibitor of CDK9 and FLT3-ITD, with Ki values of 8 and 13 nM, respectively.

METTL1-WDR4-IN-2(compound 6) is a selective metltransferase Like 1 (METTL1)-WDR4 inhibitor with an IC50 of 41 μM.

CDK2-IN-23 (Compound 17) is a kinase selective and highly potent CDK2 inhibitor (IC50 = 0.29 nM).

SelSA is a selective, orally active inhibitor for histone deacetylase 6 (HDAC6) with IC50 of 56.9 nM.

P5(PEG24)-VC-PAB-exatecan is a camptothecin-based linker-payload platform based on the highly potent camptothecin derivative exatecan.

DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM.

PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM.

LSD1/HDAC6-IN-2 (JBI-802) is an orally active LSD1/HDAC6/MAO-A inhibitor, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively.

PARP1-IN-29 is an orally active PARP-1 inhibitor with an IC50 value of 6.3 nM.

Ditercalinium chloride is an anticancer agent.

Tesirine intermediate-2 is the intermediate of Tesirine.

(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1.

Exatecan Intermediate 5 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.

Exatecan Intermediate 6 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.

Exatecan Intermediate 7 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.

Tesirine intermediate-1 is the intermediate of Tesirine.

L2H2-6OTD intermediate-2 is an intermediate of telomerase inhibitor, which can be used in the synthesis of ADC.

Exatecan analog 36 is a analog of Exatecan.

Palbociclib (PD 0332991) drochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively.

Ac-Exatecan is acetylated Exatecan.

Uridine-15N2 is the 15N labeled Uridine.