11-deoxy Corticosterone (Synonyms: DOC, NSC 11319, 21-hydroxy Progesterone) |
| Katalog-Nr.GC40394 |
11-Deoxykortikosteron ist ein Steroidhormon, das von der Nebenniere produziert wird und Mineralocorticoid-Aktivität besitzt und als Vorläufer von Aldosteron wirkt.
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Cas No.: 64-85-7
Sample solution is provided at 25 µL, 10mM.
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11-deoxy Corticosterone (DOC) is an endogenous mineralocorticoid synthesized in the zona fasciculata and zona glomerulosa of the adrenal gland. It is a metabolite of progesterone and precursor to aldosterone and corticosterone . DOC is metabolized to the neuroactive compound (3α,5α)-2,21-dihydroxypregnan-20-one (THDOC), which positively modulates GABAA receptors and produces effects similar to barbiturates in rats. Injections of naloxone and corticotropin-releasing hormone (CRH) increase, while dexamethasone decreases, DOC in cynomolgus monkeys. DOC levels are increased 3.4-fold in obese and diabetic mice.
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