2’-Deoxyadenosine-5’-diphosphate (sodium salt) (Synonyms: dADP, 2'-deoxy-ADP) |
| Katalog-Nr.GC52122 |
A nucleotide diphosphate
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Cas No.: 402491-35-4
Sample solution is provided at 25 µL, 10mM.
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2’-Deoxyadenosine-5’-diphosphate (dADP) is a purine nucleotide diphosphate.1 It inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase when used at a concentration of 0.23 mM.2 dADP levels are increased in erythrocytes isolated from patients with adenosine deaminase (ADA) deficiency, an inborn error of metabolism characterized by severe combined immunodeficiency (SCID).3
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002) 2.Lucas-Lenard, J.M., and Cohen, S.S.The inhibition of polynucleotide phosphorylase by certain substrate analoguesBiochim. Biophys. Acta123(3)471-477(1966) 3.Coleman, M.S., Donofrio, J., Hutton, J.J., et al.Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiencyJ. Biol. Chem.253(5)1619-1626(1978)
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