4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt) (Synonyms: 4-MU-α-GlcNS) |
| Katalog-Nr.GC42442 |
4-Methylumbelliferyl 2-sulfamino-2-desoxy-&7#945;-D-Glucopyranosid (Natriumsalz) ist ein fluorogenes Substrat der Heparinsulfamidase, wird zu 4-MU-α entschwefelt;-GlcNH2.
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Cas No.: 460085-45-4
Sample solution is provided at 25 µL, 10mM.
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4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.
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