5'-deoxy-5-Fluorocytidine (Synonyms: 5'-DFCR) |
| Katalog-Nr.GC42503 |
5'-deoxy-5-Fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine.
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Cas No.: 66335-38-4
Sample solution is provided at 25 µL, 10mM.
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5'-deoxy-5-Fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine . Capecitabine is converted by carboxylesterase to 5'-deoxy-5-fluorocytidine in the liver, then by cytidine deaminase to 5'-deoxy-5-fluorouridine in the liver and tumor tissues, and finally, by thymidine phosphorylase to 5-fluorouracil in tumors. The cytotoxicity of this intermediate occurs only after conversion to 5-fluorouracil.
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