8-iso-17-phenyl trinor Prostaglandin F2β (Synonyms: 8-iso-17-phenyl PGF2β) |
| Katalog-Nr.GC40992 |
Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and a potent agonist for the FP receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM. The isopropyl ester of bimatoprost is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation. 8-iso-17-phenyl PGF2β is an isomer of bimatoprost that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.
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