SirReal2 |
| Katalog-Nr.GC38491 |
A selective SIRT2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 709002-46-0
Sample solution is provided at 25 µL, 10mM.
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SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].
[1]. Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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