ADH-503 (Synonyms: (Z)-Leukadherin-1 choline) |
| Katalog-Nr.GC60040 |
ADH-503 ((Z)-Leukadherin-1-Cholin) ist ein oral aktiver und allosterischer CD11b-Agonist. ADH-503 fÜhrt zur Repolarisation tumorassoziierter Makrophagen, zur Verringerung der Anzahl tumorinfiltrierender immunsuppressiver myeloischer Zellen und verstÄrkt die Reaktionen dendritischer Zellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055362-74-6
Sample solution is provided at 25 µL, 10mM.
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ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].
ADH-503 ((Z)-Leukadherin-1 choline; 4 μM; 8 days) reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, granulocytes, eosinophils, and macrophages[1].
ADH-503 ((Z)-Leukadherin-1 choline; oral gavage; 30, 60, or 120 mg/kg; twice a day for 60 days) delayes tumor progression, leading to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. ADH-503 (oral gavage; 30, 100 mg/kg; twice a day; on days 1 and 5) has the mean half-life of 4.68 and 3.95 hours, a maximum concentration of 1716 and 2594 ng/mL and AUC0-t in the plasma of 6950 and 13962 ng.h/mL at 30 and 100 mg/kg dosing, respectively[1]. Animal Model: KPC mice [p48-CRE/Lox-stop-Lox(LSL)-KrasG12D/p53flox/flox][1]
[1]. Panni RZ, et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11(499).
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