AMG 579 |
| Katalog-Nr.GC31213 |
AMG 579 ist ein potenter, selektiver und wirksamer Inhibitor der Phosphodiesterase 10A (PDE10A) mit einem IC50 von 0,1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1227067-61-9
Sample solution is provided at 25 µL, 10mM.
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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%[1].
[1]. Hu E,et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41.
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