Amino-PEG8-Boc |
| Katalog-Nr.GC64324 |
Amino-PEG8-Boc ist ein spaltbarer PEG-ADC-Linker mit 8 Einheiten, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird. Amino-PEG8-Boc ist auch ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann.
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Cas No.: 756526-06-4
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG8-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups. WO2016207089A1.
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