Andarine (Synonyms: Andarine, S-4, SARM S-4) |
Katalog-Nr.GC13685 |
Andarine (S-4) ist ein oral aktiver und selektiver nichtsteroidaler Androgenrezeptor (AR)-Modulator (SARM) und ein partieller Agonist mit einem Ki von 4 nM. Andarine (S-4) wird als SARM mit starker und gewebeselektiver pharmakologischer In-vivo-AktivitÄt identifiziert.
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Cas No.: 401900-40-1
Sample solution is provided at 25 µL, 10mM.
Andarine (S-4) is a selective inhibitor of AR with Ki value of 4 nM [1].
Androgen receptor (AR), also known as nuclear receptor subfamily 3, group C, member 4, is a type of nuclear receptor and plays an important role in DNA-binding transcription factor that regulates gene expression [2].
Andarine is a potent AR inhibitor and has a higher affinity with the reported AR inhibitor S-1, S-2 and S-3. Using a cotransfection system, it was shown that Andarine stimulated AR-mediated transcription as high as 93% at the concentration of 10 nM. [1].
In male Sprague-Dawley rat model, administration of Andarine resulted in the growth in prostate, seminal vesicles, and levator ani muscle at a dose-dependent manner and promoted their weight being maximally to 33.8, 28.2 and 101% of intact controls, respectively. Further, it was revealed that the ED50 value of Andarine functioning on prostate, seminal vesicles, and levator ani muscle was 0.43±0.01, 0.55±0.02, and 0.14±0.01 mg/day [1].
References:
[1]. Yin, D., et al., Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther, 2003. 304(3): p. 1334-40.
[2]. Thevis, M., et al., Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom, 2011. 25(15): p. 2187-95.
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