ANI-7 |
| Katalog-Nr.GC39284 |
ANI-7 ist ein Aktivator des Aryl-Kohlenwasserstoff-Rezeptor (AhR)-Signalwegs. ANI-7 hemmt das Wachstum mehrerer Krebszellen und hemmt wirksam und selektiv das Wachstum von MCF-7-Brustkrebszellen mit einem GI50 von 0,56 μM. ANI-7 induziert CYP1-metabolisierende Monooxygenasen durch Aktivierung des AhR-Signalwegs und induziert auch DNA-SchÄden, Aktivierung der Checkpoint-Kinase 2 (Chk2), Stillstand des S-Phasen-Zellzyklus und Zelltod in empfindlichen Brustkrebs-Zelllinien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 931417-26-4
Sample solution is provided at 25 µL, 10mM.
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ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].
[1]. ilbert J, et al. (Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018 Feb;93(2):168-177. [2]. Baker JR, et al. Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro. ChemMedChem. 2018 Jul 18;13(14):1447-1458. [3]. Mark Tarleton, et al. Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. Medicinal Chemistry Communication. January 20112. (1):31-37.
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