Aripiprazole N-oxide (Synonyms: Aripiprazole N1-Oxide) |
| Katalog-Nr.GC52024 |
A metabolite of aripiprazole
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 573691-09-5
Sample solution is provided at 25 µL, 10mM.
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Aripiprazole N-oxide is a metabolite of the atypical antipsychotic aripiprazole .1,2 It is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.3 Aripiprazole N-oxide is a potential impurity found in commercial preparations of aripiprazole.1
1.Filijovic, N.D., Pavlovi?, A., Nikolic, K., et al.Validation of an HPLC method for determination of aripiprazole and its impurities in pharmaceuticalsActa Chromatagr.26(1)13-28(2014) 2.Satyanarayana, B., Sumalatha, Y., Kumar, S.S., et al.Synthesis and characterization of N-oxides and metabolites of antipsychotic drug, aripiprazoleHeterocycl. Commun.11(6)485-490(2005) 3.Kubo, M., Koue, T., Inaba, A., et al.Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLEDrug Metab. Pharmacokinet.20(1)55-64(2005)
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